The role of estrogen receptors

Estrogen receptors play an important role in certain types of breast cancer, such as HR-positive breast cancer.

HR-positive advanced or metastatic breast cancer

Some breast cancers are known as estrogen receptor-positive (ER+), which is a type of HR-positive breast cancer. Your doctor may use the term ER+ advanced or metastatic breast cancer if you have this type of cancer.

In ER+ advanced or metastatic breast cancer:

  • Estrogen can contribute to the growth and spread of cancer by connecting to specialized receivers called estrogen receptors
  • When estrogen connects to estrogen receptors, it sends signals telling tumor cells to divide and multiply
  • When these signals are blocked, tumor cells cannot divide and multiply

FASLODEX, a hormonal medicine designed to target the estrogen receptor, may be able to help. When the estrogen receptor is blocked, estrogen’s ability to influence cancer growth is reduced.

HR=hormone receptor.

IMPORTANT SAFETY INFORMATION ABOUT FASLODEX® (fulvestrant) injection

    You should not receive FASLODEX if you have had an allergic reaction to fulvestrant or any of the ingredients in FASLODEX. Talk to your health care provider if you experience symptoms of an allergic reaction to FASLODEX, which may include itching or hives; swelling of your face, lips, tongue, or throat; and trouble breathing.

    Before receiving FASLODEX, tell your health care provider about all of your medical conditions, including if you:

  • Have a low level of platelets in your blood or bleed easily. Especially, tell your health care provider if you take a blood thinner medicine (anticoagulant)
  • Have liver problems
  • Are pregnant or plan to become pregnant, because FASLODEX can harm your unborn baby. Your health care provider may perform a pregnancy test within 7 days before starting FASLODEX. Women who are able to become pregnant should use effective birth control during treatment with FASLODEX and for 1 year after the last dose. Tell your health care provider right away if you become pregnant or think you are pregnant while on FASLODEX
  • Are breastfeeding or plan to breastfeed. It is not known if FASLODEX passes into breast milk. Do not breastfeed during treatment with FASLODEX and for 1 year after the final dose. Talk to your health care provider about the best way to feed your baby during this time

Tell your health care provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. FASLODEX may affect the way other medicines work, and other medicines may affect how FASLODEX works.

FASLODEX is administered by your health care provider as an injection into the muscle of each buttock. Your health care provider may change your dose of FASLODEX if needed.

FASLODEX may cause serious side effects, including injection site–related nerve damage. Call your health care provider if you develop any of the following symptoms in your legs following a FASLODEX injection: numbness, tingling, or weakness.

Common side effects of FASLODEX include injection site pain; nausea; muscle, joint, and bone pain; headache; back pain; tiredness; pain in arms, hands, legs or feet; hot flashes; vomiting; loss of appetite; weakness; cough; shortness of breath; constipation; increased liver enzymes; and diarrhea.

Tell your health care provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with FASLODEX. For more information, ask your health care provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-10881-800-FDA-1088.

Approved Uses for FASLODEX

FASLODEX is a prescription medicine used to treat advanced breast cancer or breast cancer that has spread to other parts of the body (metastatic).

FASLODEX may be used alone, if you have gone through menopause, and your advanced breast cancer is:

  • hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative and has not been previously treated with endocrine therapy

or

  • HR-positive and has progressed after endocrine therapy

FASLODEX may be used in combination with ribociclib, if you have gone through menopause, and your advanced or metastatic breast cancer is HR-positive and HER2-negative, and has not been previously treated with endocrine therapy or has progressed after endocrine therapy.

FASLODEX may be used in combination with palbociclib or abemaciclib if your advanced or metastatic breast cancer is HR-positive and HER2-negative, and has progressed after endocrine therapy.

When FASLODEX is used in combination with palbociclib, abemaciclib or ribociclib, also read the Patient Information for the prescribed product.

It is not known if FASLODEX is safe and effective in children or in people with severe liver problems.

Please see FASLODEX Prescribing Information with Patient Information.

 
 
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IMPORTANT SAFETY INFORMATION ABOUT FASLODEX® (fulvestrant) injection

    You should not receive FASLODEX if you have had an allergic reaction to fulvestrant or any of the ingredients in FASLODEX. Talk to your health care provider if you experience symptoms of an allergic reaction to FASLODEX, which may include itching or hives; swelling of your face, lips, tongue, or throat; and trouble breathing.

    Before receiving FASLODEX, tell your health care provider about all of your medical conditions, including if you:

  • Have a low level of platelets in your blood or bleed easily. Especially, tell your health care provider if you take a blood thinner medicine (anticoagulant)
  • Have liver problems
  • Are pregnant or plan to become pregnant, because FASLODEX can harm your unborn baby. Your health care provider may perform a pregnancy test within 7 days before starting FASLODEX. Women who are able to become pregnant should use effective birth control during treatment with FASLODEX and for 1 year after the last dose. Tell your health care provider right away if you become pregnant or think you are pregnant while on FASLODEX
  • Are breastfeeding or plan to breastfeed. It is not known if FASLODEX passes into breast milk. Do not breastfeed during treatment with FASLODEX and for 1 year after the final dose. Talk to your health care provider about the best way to feed your baby during this time

Tell your health care provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. FASLODEX may affect the way other medicines work, and other medicines may affect how FASLODEX works.

FASLODEX is administered by your health care provider as an injection into the muscle of each buttock. Your health care provider may change your dose of FASLODEX if needed.

FASLODEX may cause serious side effects, including injection site–related nerve damage. Call your health care provider if you develop any of the following symptoms in your legs following a FASLODEX injection: numbness, tingling, or weakness.

Common side effects of FASLODEX include injection site pain; nausea; muscle, joint, and bone pain; headache; back pain; tiredness; pain in arms, hands, legs or feet; hot flashes; vomiting; loss of appetite; weakness; cough; shortness of breath; constipation; increased liver enzymes; and diarrhea.

Tell your health care provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with FASLODEX. For more information, ask your health care provider or pharmacist. You may report side effects to the FDA at 1-800-FDA-10881-800-FDA-1088.

Approved Uses for FASLODEX

FASLODEX is a prescription medicine used to treat advanced breast cancer or breast cancer that has spread to other parts of the body (metastatic).

FASLODEX may be used alone, if you have gone through menopause, and your advanced breast cancer is:

  • hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative and has not been previously treated with endocrine therapy

or

  • HR-positive and has progressed after endocrine therapy

FASLODEX may be used in combination with ribociclib, if you have gone through menopause, and your advanced or metastatic breast cancer is HR-positive and HER2-negative, and has not been previously treated with endocrine therapy or has progressed after endocrine therapy.

FASLODEX may be used in combination with palbociclib or abemaciclib if your advanced or metastatic breast cancer is HR-positive and HER2-negative, and has progressed after endocrine therapy.

When FASLODEX is used in combination with palbociclib, abemaciclib or ribociclib, also read the Patient Information for the prescribed product.

It is not known if FASLODEX is safe and effective in children or in people with severe liver problems.

Please see FASLODEX Prescribing Information with Patient Information.