Treatment options in metastatic breast cancer

Selecting a treatment option

Women with metastatic breast cancer have several treatment options to consider. Your pathology report, which contains detailed information about your diagnosis, plays an important role in defining your treatment plan. You and your doctor can use this information to make treatment decisions.

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Hormonal treatment

Hormonal treatment, which travels in the bloodstream, has been prescribed to treat hormone receptor-positive metastatic breast cancer for many years and may be used to reduce the growth or spread of breast cancer. If cancer is the type that may be sensitive to estrogen, hormonal treatment may keep estrogen from helping the cancer cells to grow and divide. The presence of hormone receptors in the tumor is the best way to predict response to hormonal treatment for breast cancer. Speak to your doctor about the different types of hormonal treatments—you may have been prescribed a hormonal therapy at a different point in your treatment journey.

 
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Chemotherapy

Chemotherapy, which travels in the bloodstream, is the use of drugs that target and destroy rapidly dividing cells, including cancer cells. It can be used in metastatic breast cancer to shrink cancerous tumors.

 
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Biologically targeted therapy

Biologically targeted systemic therapies fight cancer by targeting specific features of cancer cells. They may be added to chemotherapy treatments. For example, there are specific treatments that target breast cancer cells that make too much of a protein called HER2/neu. This targeted therapy can block the effects of the HER2/neu proteins, limiting tumor cell growth.

 
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Radiation therapy

Radiation therapy uses high-energy waves or streams of particles to hinder the growth of or kill cancer cells. It can be used after breast-conserving surgery, after mastectomy, or to treat metastatic tumors in the bones or brain. Depending on where in the body cancer spread to, radiation therapy can also be used in the chest wall, breast, and lymph nodes. Radiation therapy is referred to as a local therapy because it treats a specific area of the body instead of the entire body.

 
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Surgery

Surgery is not commonly used in metastatic breast cancer but may be an option for some women. Surgery may be used (either in conjunction with radiation therapy or on its own) to help avoid broken bones, cancer cell blockages in the liver, or to ease pain and other symptoms. Like radiation, surgery is considered a local therapy because it treats a specific area of the body instead of the entire body.

 

IMPORTANT SAFETY INFORMATION

  • You should not receive FASLODEX if you have had an allergic reaction to any of the ingredients in FASLODEX. Symptoms of an allergic reaction to FASLODEX may include: itching; swelling of your face, lips, tongue, or throat; trouble breathing
  • Before receiving FASLODEX, tell your healthcare provider about all of your medical conditions, including if you:

  • Have a low level of platelets in your blood or bleed easily. Especially tell your healthcare provider if you take a blood thinner medicine (anticoagulants)
  • Have liver problems
  • Are pregnant or plan to become pregnant, as FASLODEX can harm your unborn baby. Females who are able to become pregnant should use effective birth control during treatment with FASLODEX and for one year after the last dose. Tell your healthcare provider right away if you become pregnant or think you are pregnant while on FASLODEX
  • Are breast-feeding or plan to breast-feed. It is not known if FASLODEX passes into breast milk. Do not breast-feed during treatment with FASLODEX and for one year after the last dose. Talk to your healthcare provider about the best way to feed your baby during this time
  • FASLODEX is administered as a shot into the muscle of your buttock.

    FASLODEX may cause injection site related nerve damage. Call your healthcare provider if you develop any of the following symptoms in your legs following a FASLODEX injection: numbness; tingling; weakness.

    The most common side effects of FASLODEX include: injection site pain; nausea; muscle, joint, and bone pain; headache; tiredness; hot flashes; vomiting; loss of appetite; weakness; cough; shortness of breath, constipation; and increased liver enzymes.

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with FASLODEX. For more information, ask your healthcare provider or pharmacist.

Approved Uses for FASLODEX

FASLODEX is a prescription medicine used to treat:

  • hormone receptor (HR)-positive breast cancer in women who have gone through menopause whose disease has spread after treatment with antiestrogen medicine, OR
  • HR-positive, human epidermal growth factor receptor 2 (HER2)‐negative breast cancer whose disease has spread to other parts of the body (metastatic) in combination with palbociclib in women with disease progression after hormonal therapy
  • When FASLODEX is used in combination with palbociclib, please also see the palbociclib Patient Information.

Please see FASLODEX Prescribing Information with Patient Information.

 
 
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IMPORTANT SAFETY INFORMATION

  • You should not receive FASLODEX if you have had an allergic reaction to any of the ingredients in FASLODEX. Symptoms of an allergic reaction to FASLODEX may include: itching; swelling of your face, lips, tongue, or throat; trouble breathing
  • Before receiving FASLODEX, tell your healthcare provider about all of your medical conditions, including if you:

  • Have a low level of platelets in your blood or bleed easily. Especially tell your healthcare provider if you take a blood thinner medicine (anticoagulants)
  • Have liver problems
  • Are pregnant or plan to become pregnant, as FASLODEX can harm your unborn baby. Females who are able to become pregnant should use effective birth control during treatment with FASLODEX and for one year after the last dose. Tell your healthcare provider right away if you become pregnant or think you are pregnant while on FASLODEX
  • Are breast-feeding or plan to breast-feed. It is not known if FASLODEX passes into breast milk. Do not breast-feed during treatment with FASLODEX and for one year after the last dose. Talk to your healthcare provider about the best way to feed your baby during this time
  • FASLODEX is administered as a shot into the muscle of your buttock.

    FASLODEX may cause injection site related nerve damage. Call your healthcare provider if you develop any of the following symptoms in your legs following a FASLODEX injection: numbness; tingling; weakness.

    The most common side effects of FASLODEX include: injection site pain; nausea; muscle, joint, and bone pain; headache; tiredness; hot flashes; vomiting; loss of appetite; weakness; cough; shortness of breath, constipation; and increased liver enzymes.

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all of the possible side effects with FASLODEX. For more information, ask your healthcare provider or pharmacist.

Approved Uses for FASLODEX

FASLODEX is a prescription medicine used to treat:

  • hormone receptor (HR)-positive breast cancer in women who have gone through menopause whose disease has spread after treatment with antiestrogen medicine, OR
  • HR-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer whose disease has spread to other parts of the body (metastatic) in combination with palbociclib in women with disease progression after hormonal therapy
  • When FASLODEX is used in combination with palbociclib, please also see the palbociclib Patient Information.